Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis.
Masahiro TakeuchiPaula T VidigalMateus T GuerraMelanie A HundtMarie E RobertMaria Olave-MartinezSatoshi AokiTanaporn KhamphayaRemco KerstenEmma KruglovRandolph de la Rosa RodriguezJesus Maria BanalesMichael H NathansonJittima WeerachayaphornPublished in: Gut (2020)
Neutrophils bind to ITGB1 on cholangiocytes to contribute to cholestasis in AH. This previously unrecognised role for cholangiocytes in this disease alters our understanding of its pathogenesis and identifies new therapeutic targets.