Mitochondrial transfer from bone mesenchymal stem cells protects against tendinopathy both in vitro and in vivo.

Bing WeiMingliang JiYucheng LinShanzheng WangYuxi LiuRui GengXinyue HuLi XuZhuang LiWeituo ZhangJun Lu

Published in: Stem cell research & therapy (2023)

MSCs rescued distressed tenocytes from apoptosis by transferring mitochondria. This provides evidence that mitochondrial transfer is one mechanism by which MSCs exert their therapeutic effects on damaged tenocytes.

Keyphrases

mesenchymal stem cells
oxidative stress
umbilical cord
cell death
bone marrow
endoplasmic reticulum stress
cell therapy
bone mineral density
cell cycle arrest
stem cells
soft tissue
electron transfer
platelet rich plasma
bone regeneration
postmenopausal women
endoplasmic reticulum