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Genotoxic aldehydes in the hematopoietic system.

Meng WangFelix A DinglerK J Patel
Published in: Blood (2022)
Reactive aldehydes are potent genotoxins that threaten the integrity of hematopoietic stem cells and blood production. To protect against aldehydes, mammals have evolved a family of enzymes to detoxify aldehydes, and the Fanconi anemia DNA repair pathway to process aldehyde-induced DNA damage. Loss of either protection mechanisms in humans results in defective hematopoiesis and predisposition to leukemia. This review will focus on the impact of genotoxic aldehydes on hematopoiesis, the sources of endogenous aldehydes, and potential novel protective pathways.
Keyphrases
  • dna repair
  • dna damage
  • stem cells
  • bone marrow
  • oxidative stress
  • chronic kidney disease
  • acute myeloid leukemia
  • dna damage response
  • endothelial cells
  • climate change
  • drug induced