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Pulmonary ductal coarctation and left pulmonary artery interruption; pathology and role of neural crest and second heart field during development.

Adriana C Gittenberger-de GrootJoshua C PetersonLambertus J WisseArno A W RoestRobert E PoelmannRegina BökenkampNynke J ElzengaMark HazekampMargot M BartelingsMonique R M JongbloedMarco C DeRuiter
Published in: PloS one (2020)
Side-way connection of the DA to the left pulmonary artery is a congenital anomaly. The primary problem is a stunted development of the pulmonary push leading to pulmonary stenosis/atresia and a subsequent lack of proper incorporation of the ventral segment into the aortic sac. Clinically, the aberrant smooth muscle tissue of the ductus arteriosus should be addressed to prohibit development of severe pulmonary ductal coarctation or even interruption of the left pulmonary artery.
Keyphrases
  • pulmonary artery
  • pulmonary hypertension
  • pulmonary arterial hypertension
  • coronary artery
  • smooth muscle
  • heart failure
  • spinal cord
  • aortic valve
  • early onset
  • left ventricular