Use of multigene-panel identifies pathogenic variants in several CRC-predisposing genes in patients previously tested for Lynch Syndrome.

Maren F HansenJostein JohansenAnna E SylvanderInga BjørnevollBente A Talseth-PalmerLiss A S LavikAlexandre XavierLars F EngebretsenRodney J ScottFinn DrabløsWenche Sjursen

Published in: Clinical genetics (2017)

In conclusion, we found a promising DNA variant in more than 25 % of the patients, which shows that gene panel testing is a more effective method to identify germline variants in CRC patients compared to a single gene approach.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
genome wide
prognostic factors
gene expression
dna methylation
dna damage
oxidative stress
single molecule