CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5-lipoxygenase.

Yuli LinQian CaiYu ChenTiancong ShiWeiren LiuLi MaoBo DengZhen YingYuan GaoHaoyang LuoXuguang YangXiaowu HuangYing-Hong ShiRui He

Published in: Hepatology (Baltimore, Md.) (2021)

Our study reveals a role for CAFs in orchestrating the optimal cancer stemness-enhancing microenvironment by educating MDSCs, and suggests the 5-LO/LTB4-BLT2 axis as promising therapeutic targets for ICC chemoresistance by targeting cancer stemness.

Keyphrases

stem cells
papillary thyroid
epithelial mesenchymal transition
squamous cell
induced apoptosis
lymph node metastasis
squamous cell carcinoma
cell cycle arrest
cell proliferation
young adults
cell death