The Autoimmune Manifestations in Patients with Genetic Defects in the B Cell Development and Differentiation Stages.

Gholamreza AziziMina Fattah HesariNiusha SharifinejadFarimah FayyazZahra ChavoshzadehSeyed Alireza MahdavianiMahnaz Seifi AlanMahnaz JameeMarzieh TavakolHoma SadriEhsan ShahrestanakiMohammad NabaviSareh Sadat EbrahimiAfshin ShirkaniAhmad Vosughi MotlaghSamaneh DelavariSeyed Erfan RasouliMarzie EsmaeiliFereshte SalamiReza YazdaniNima RezaeiHassan Abolhassani

Published in: Journal of clinical immunology (2023)

Our results demonstrated that gene mutations involved in human B cell terminal stage development mainly LRBA gene defect have the highest association with autoimmunity.

Keyphrases

genome wide
endothelial cells
copy number
multiple sclerosis
gene expression
dna methylation
drug induced
genome wide analysis