Pathways and microbiome modifications related to surgery and enterocolitis in Hirschsprung disease.
Roberto BiassoniEddi Di MarcoMargherita SquillarioElisabetta UgolottiManuela MosconiMaria Grazia FaticatoGirolamo MattioliStefano AvanziniAlessio Pini PratoPublished in: Pediatric surgery international (2021)
Our study, addressing microbiome dynamics, demonstrated relevant changes after surgical manipulation. Alpha-diversity analyses indicated that surgery deeply affects microbiome composition. Proteobacteria and Enterobacteriaceae seem to play a pivotal role in HAEC occurrences. Several virulence factors, such as fimbriae or pili, might explain the HAEC-predisposing potential of selected microbiomes. These results suggest some innovative therapeutic approaches that deserve to be tested in appropriate clinical trials.
Keyphrases
- minimally invasive
- coronary artery bypass
- clinical trial
- pseudomonas aeruginosa
- escherichia coli
- surgical site infection
- staphylococcus aureus
- multidrug resistant
- antimicrobial resistance
- percutaneous coronary intervention
- klebsiella pneumoniae
- atrial fibrillation
- acute coronary syndrome
- low birth weight
- risk assessment
- preterm birth