Hypomethylation in HBV integration regions aids non-invasive surveillance to hepatocellular carcinoma by low-pass genome-wide bisulfite sequencing.

Haikun ZhangPeiling DongShicheng GuoChengcheng TaoWei ChenWenmin ZhaoJiakang WangRamsey CheungAugusto VillanuevaJian FanHuiguo DingSteven J SchrodiDake ZhangChangqing Zeng

Published in: BMC medicine (2020)

Hypomethylation around viral integration sites aids low-pass cfDNA WGBS to serve as a non-invasive approach for early HCC detection, and inspire future efforts on tumor surveillance for oncovirus with integration activity.

Keyphrases

genome wide
public health
antiretroviral therapy
hepatitis b virus
dna methylation
sars cov
single cell
current status
quality improvement
liver failure
loop mediated isothermal amplification
copy number