Epigenetic regulation of innate immune memory in microglia.

Xiaoming ZhangLaura KrachtAntonio M LerarioMarissa L DubbelaarNieske BrouwerEvelyn M WesselingErik W G M BoddekeBart J L EggenSusanne M Kooistra

Published in: Journal of neuroinflammation (2022)

This study provides insight into epigenetic profiles and transcription factor networks associated with transcriptional signatures of tolerized and trained microglia in vivo, leading to a better understanding of innate immune memory of microglia.

Keyphrases

innate immune
transcription factor
inflammatory response
neuropathic pain
working memory
gene expression
dna methylation
spinal cord injury
spinal cord
resistance training
oxidative stress
body composition
heat shock