Alternative mechanism of action of the DNP PtIV prodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway.
Olga O KrasnovskayaDaniil SpectorAlexander S ErofeevPeter GorelkinRoman A AkasovDmitry A SkvortsovAlexander TrigubKsenia VlasovaAlevtina SemkinaNikolay ZykElena K BeloglazkinaAlexander MajougaPublished in: Dalton transactions (Cambridge, England : 2003) (2021)
In a recent research paper Dr. Suxing Jin et al. reported two multispecific PtIV complexes DNP and NP with non-steroidal anti-inflammatory drug naproxen (NPX) as the axial ligand(s). Herein, we clarify the mechanism of action of DNP, its therapeutic target and intracellular redox-status.