Implication of CD69+ CD103+ tissue-resident-like CD8+ T cells as a potential immunotherapeutic target for cholangiocarcinoma.

Hyung-Don KimSeongju JeongSeongyeol ParkYong Joon LeeYoung Seok JuDanbee KimGi-Won SongJae Hoon LeeSang-Yeob KimJaehoon ShinEui-Cheol ShinShin Hwang Changhoon Yoo Su-Hyung Park

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

CD69+ CD103+ TRM-like CD8+ TILs represent prominent tumour-specific immune responses and hold promise as a potential therapeutic target in ICC patients. Differential TRM-related features of ICCs may help develop future immunotherapeutic strategies such as maximizing TRM responses or inhibiting pathways contributing to immune evasion.

Keyphrases

immune response
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
human health
risk assessment
dendritic cells
big data
quality improvement
machine learning
patient reported outcomes
artificial intelligence