Association of HLA-DQ Heterodimer Residues -18β and β57 With Progression From Islet Autoimmunity to Diabetes in the Diabetes Prevention Trial-Type 1.

Lue Ping ZhaoJay SkylerGeorge K PapadopoulosAlberto PuglieseJames Antonio NajeraGeorge P BondinasAntonis K MoustakasRuihan WangChul-Woo PyoWyatt C NelsonDaniel E GeraghtyLernmark Åke

Published in: Diabetes care (2022)

HLA-DQ structural motifs appear to modulate progression from islet autoimmunity to diabetes among at-risk relatives with islet autoantibodies. Residue -18β within the signal peptide may be related to levels of protein synthesis and β57 to stability of the peptide-DQab trimolecular complex.

Keyphrases

type diabetes
cardiovascular disease
glycemic control
celiac disease
clinical trial
systemic lupus erythematosus
study protocol
phase ii
metabolic syndrome
amino acid