Genetic predisposition to high BMI increases risk of early life respiratory infections and episodes of severe wheeze and asthma.

Signe Kjeldgaard JensenCasper-Emil Tingskov PedersenKasper Fischer-RasmussenMathias Elsner MelgaardNicklas BrustadJulie Nyholm KyvsgaardNilo VahmanAnn-Marie Malby SchoosJessica Lasky-SuBo ChawesAnders EliasenKlaus Bønnelykke

Published in: The European respiratory journal (2024)

Children with genetic predisposition to higher BMI had increased risk of LRTI and severe wheeze, independent of the child's current BMI. These results shed further light on the complex relationship between BMI and asthma.

Keyphrases

body mass index
early life
weight gain
chronic obstructive pulmonary disease
lung function
genome wide
early onset
young adults
mental health
allergic rhinitis
copy number
physical activity