Resistance to osimertinib in advanced EGFR-mutated NSCLC: a prospective study of molecular genotyping on tissue and liquid biopsies.

Alessandro LeonettiM VerzèRoberta MinariF PerroneL GnettiP BordiM PluchinoR NizzoliC AzzoniL BottarelliC A M LagrastaG MazzaschiS ButiD GasparroA CosenzaL FerriM MajoriM De FilippoL AmpolliniS La MonicaR AlfieriE M SiliniFrancesco Gelsomino

Published in: British journal of cancer (2023)

Resistance to osimertinib demonstrated to be highly heterogeneous, with MET amplification the main mechanism. Plasma genotyping is a relevant complementary tool which might integrate tissue analysis for the study of resistance mechanisms.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
advanced non small cell lung cancer
tyrosine kinase
high throughput
brain metastases
gene expression
ionic liquid
label free