Genome-wide Epigenetic Study of Chronic Rhinosinusitis Tissues Reveals Dysregulated Inflammatory, Immunologic and Remodeling Pathways.

Tripti BrarSaurabh BahetiMichael J MarinoHirohito KitaDevyani Lal

Published in: American journal of rhinology & allergy (2023)

Differential patterns of methylation were identified between controls and CRS, CRSwNP, and CRSsNP. Epigenetic, environmentally-induced changes related to novel, inflammatory, immunologic, and remodeling pathways appear to affect epithelial integrity, cell proliferation, homeostasis, vascular permeability, and other yet uncharacterized pathways and genes.

Keyphrases

genome wide
dna methylation
gene expression
cell proliferation
chronic rhinosinusitis
oxidative stress
copy number
high glucose
endothelial cells
cell cycle
drug induced
pi k akt
transcription factor
bioinformatics analysis
genome wide identification