Looking into the Kinetics of NT-proBNP and sST2 Changes in Patients with Heart Failure Treated with Sacubitril/Valsartan: A Hint to Different Therapeutic Pathways.
Massimo MapelliIrene MattavelliElisabetta SalvioniAlice BonomiNicolò CapraPietro PalermoCristina BanfiStefania PaolilloMaria Luisa BiondiPiergiuseppe AgostoniPublished in: Drugs in R&D (2023)
These findings suggest that, in patients with HF, sacubitril/valsartan effects on the cardiovascular system share a double pathway: a first, hemodynamic, faster pathway and a second, non-hemodynamic anti-fibrotic, delayed one. Both likely contribute to the sacubitril/valsartan benefits in HFrEF.