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Ileocolonic Healing After Extended Small Bowel Resection in Mice: NOD2 Deficiency Impairs Anastomotic Healing and Postoperative Outcome.

Maria B WitteJohannes ReinerKaren BannertRobert JasterChristian MaschmeierClemens SchafmayerGeorg LamprechtPeggy Berlin
Published in: Inflammatory bowel diseases (2022)
We found that Nod2 deficiency results in significantly reduced bursting pressure after ileocecal resection. This effect is mediated via an increased matrix turnover. Patients with genetic NOD2 variations may be prone to anastomotic failure after bowel resection.
Keyphrases
  • small bowel
  • rectal cancer
  • innate immune
  • replacement therapy
  • genome wide
  • adipose tissue
  • metabolic syndrome
  • skeletal muscle
  • smoking cessation