Estimating Bidirectional Transitions and Identifying Predictors of Mild Cognitive Impairment.

The nature of bidirectional transitions cannot be ignored in multi-dimensional MCI research. We found that post-reversion participants remained at an increased risk of progression to MCI or dementia over the longer term and experienced recurrent reversions. Our findings may serve as a valuable reference for future research and enable healthcare professionals to better develop proactive management plans and targeted interventions.