Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom Onset.
Yan LiDaniel YenRachel D HendrixBrian A GordonSibonginkhosi DlaminiNicolas R BarthélemyAndrew J AschenbrennerRachel L HensonElizabeth M HerriesKatherine VolluzKristopher KirmessStephanie EastwoodMatthew MeyerMaren HellerLea JarrettEric McDadeDavid M HoltzmanTammie L S BenzingerJohn C MorrisRandall J BatemanChengjie XiongSuzanne E SchindlerPublished in: Annals of neurology (2024)
The use of an amyloid clock enabled visualization and analysis of biomarker changes as a function of estimated years from symptom onset in sporadic AD. This study demonstrates that estimated years from symptom onset based on an amyloid clock can be used as a continuous staging measure for sporadic AD and aligns with findings in autosomal dominant AD. ANN NEUROL 2024.