ARHGEF7 (β-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function.

Jun MatsudaMirela MaierLamine AoudjitCindy BaldwinTomoko Takano

Published in: Journal of the American Society of Nephrology : JASN (2020)

These findings indicate that β-PIX is required for the maintenance of podocyte architecture and glomerular function via Cdc42 and its downstream Yes-associated protein activities. This appears to be the first evidence that a Rho-guanine nucleotide exchange factor plays a critical role in podocytes.

Keyphrases

diabetic nephropathy
high glucose
endothelial cells
protein kinase
smooth muscle