Effects of crystalloid, hyper-oncotic albumin, and iso-oncotic albumin on lung and kidney damage in experimental acute lung injury.
Renata de S MendesMilena V OliveiraGisele A PadilhaNazareth N RochaCintia L SantosLigia A MaiaMarcos V de S FernandesFernanda F CruzPriscilla C OlsenVera L CapelozziMarcelo Gama de AbreuPaolo PelosiPatricia R M RoccoPedro Leme SilvaPublished in: Respiratory research (2019)
In a rat model of ALI, both iso-oncotic and hyper-oncotic albumin solutions were associated with less lung injury compared to Ringer's lactate. However, hyper-oncotic albumin resulted in greater kidney damage than iso-oncotic albumin. This experimental study is a step towards future clinical designs.
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