Quantification of right ventricular amyloid burden with 18F-florbetapir positron emission tomography/computed tomography and its association with right ventricular dysfunction and outcomes in light-chain amyloidosis.
Yesh DatarOlivier F ClercSarah A M CuddySirwoo KimAlexandra TaylorJocelyn Canseco NeriDominik C BenzGiada BianchiAndrew J YeeVaishali SanchorawalaFrederick L RubergHeather LandauRonglih LiaoMarie Foley KijewskiMichael Jerosch-HeroldRaymond Y KwongMarcelo F Di CarliRodney H FalkSharmila DorbalaPublished in: European heart journal. Cardiovascular Imaging (2024)
This study shows for the first time that 18F-florbetapir PET/CT identifies early RV amyloid in systemic AL amyloidosis prior to alterations in RV structure and function. Increasing RV amyloid on 18F-florbetapir PET/CT is associated with worse RV structure and function, predicts RV dysfunction, and predicts MACE. These results imply a central role for RV amyloid in the pathogenesis of RV dysfunction.