CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells.

Lei ZhangYidong LiChaohua HuYangmin ChenZhuo ChenZhe-Sheng ChenJian-Ye ZhangShuo Fang

Published in: Molecular cancer (2022)

CDK6-PI3K as a new target signaling axis to reverse ABCB1-mediated MDR is reported for the first time in cancers. Pathways leading to inhibition of cancer cell proliferation were revealed to be accompanied by CDK6 deficiency.

Keyphrases

cell cycle
cell proliferation
multidrug resistant
papillary thyroid
young adults
replacement therapy
signaling pathway
smoking cessation