Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases.
Katherine A HoadleyMarni B SiegelKrishna L KanchiChristopher A MillerLi DingWei ZhaoXiaping HeJoel S ParkerMichael C WendlRobert S FultonRyan T DemeterRichard K WilsonLisa A CareyCharles M PerouElaine R MardisPublished in: PLoS medicine (2016)
Our findings suggest that multiclonal seeding may be common amongst basal-like breast cancers. In these two patients, mutations and DNA copy number changes in the primary tumors appear to have had a biologic impact on metastatic potential, whereas mutations arising in the metastases were much more likely to be passengers.
Keyphrases
- copy number
- mitochondrial dna
- end stage renal disease
- ejection fraction
- newly diagnosed
- rheumatoid arthritis
- chronic kidney disease
- genome wide
- small cell lung cancer
- prognostic factors
- peritoneal dialysis
- circulating tumor
- cell free
- single cell
- risk assessment
- young adults
- gene expression
- patient reported
- nucleic acid
- breast cancer risk