Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation.

Xin TangShuang ZhaoJieqiong LiuXiameng LiuXinqi ShaChanggao HuangLulu HuShixiu SunYuanqing Gao Hongshan Chen Zhi-Ren ZhangDongjin WangYuexi GuShaoliang ChenLian-Sheng WangAihua GuFeng Chen Jun PuXin ChenBo Yu Liping Xie Zheng-Rong Huang Yi Han Yong Ji

Published in: Circulation research (2023)

We identified a novel species of GSNOR localized in mitochondria and found mitochondrial GSNOR plays an essential role in maintaining mitochondrial homeostasis through ANT1 denitrosylation, which provides a potential novel therapeutic target for HF.

Keyphrases

oxidative stress
left ventricular
cell death
risk assessment
mouse model
climate change
human health
endoplasmic reticulum