Investigating protein-excipient interactions of a multivalent V<sub>HH</sub> therapeutic protein using NMR spectroscopy.
Jainik PanchalBradley T FalkValentyn AntochshukMark A McCoyPublished in: mAbs (2022)
Fab Fragment antigen-binding; Fc Fragment crystallizable; HMW High molecular weight; ∆HMW Difference between HMW species at stress temperature and 5°C controls; IgG Immunoglobulin G; mAbs Monoclonal antibodies; MV-V<sub>HH</sub> Multivalent V<sub>HH</sub> molecule with the format aC-L<sub>1</sub>-aC-L<sub>1</sub>-aD; NMR Nuclear magnetic resonance; scFv Single-chain fragment variable; SEC Size-exclusion chromatography; V<sub>HH</sub> Variable domain of Heavy chain of Heavy chain-only antibody.