Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis.

Alexander Guy ThompsonElizabeth GrayMarie-Laëtitia ThézénasPhilip D CharlesSamuel EvettsMichele T HuKevin TalbotRoman FischerBenedikt M KesslerMatthew C Kiernan

Published in: Annals of neurology (2018)

Neuroinflammatory mechanisms have been consistently implicated through various experimental paradigms. These results support a key role for macrophage activity in ALS pathogenesis, offering novel target engagement and pharmacodynamic biomarkers for neuroinflammation-focused ALS therapy. Ann Neurol 2018;83:258-268.

Keyphrases

cerebrospinal fluid
amyotrophic lateral sclerosis
adipose tissue
traumatic brain injury
social media
lipopolysaccharide induced
lps induced
stem cells
inflammatory response