Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school-aged children with obesity/overweight and with normal weight.

Lizbeth Josefina González-HerreraJorge Zavala-CastroClaudia Ayala-CáceresGerardo Pérez-MendozaMaría José López-GonzálezDoris Pinto-EscalanteThelma Canto-CetinaMaría Guadalupe García-EscalanteRodrigo Rubi-CastellanosSilvina Contreras-CapetilloFernando Herrera-SanchezNina Méndez-DomínguezAlberto Alcocer-Gamboa

Published in: American journal of human biology : the official journal of the Human Biology Council (2018)

The FTO SNP rs1421085 is a genetic factor associated with obesity in Mayan school-aged children. FTO SNPs rs1421085 and rs9939609 affect genetic susceptibility for obesity only in girls, whereas, SNP rs8057044 and CNV are associated with overweight status only in boys.

Keyphrases

weight loss
genome wide
copy number
weight gain
physical activity
insulin resistance
metabolic syndrome
type diabetes
mitochondrial dna
young adults
dna methylation
mental health
body mass index
high fat diet induced
gene expression
skeletal muscle
body weight