A multimeric MRI contrast agent based on a closo-borane scaffold bearing modified AAZTA chelates on the periphery.
Shatadru ChakravartySaurav J SarmaLalit N GoswamiQuan-Yu CaiErik M ShapiroM Frederick HawthorneLixin MaPublished in: Chemical communications (Cambridge, England) (2019)
A multimeric MRI contrast agent based on the closo-borane motif is reported. Twelve copies of a modified AAZTA chelate with an alkyne end group are appended on an azide-functionalized closo-borane motif using Cu(i) catalyzed click chemistry. The presence of two water molecules on the Gd-bound AAZTA chelate results in high relaxivity for the closomer in vitro/in vivo.