Impact of B Cell Depletion on COVID-19 in Kidney Transplant Recipients.
Naohiro AidaTaihei ItoKei KuriharaIzumi HiratsukaMegumi ShibataAtsushi SuzukiMidori HasegawaTakashi KenmochiPublished in: Viruses (2023)
Kidney transplant recipients are patients at high risk for coronavirus disease 2019 (COVID-19) due to being on immunosuppressive therapy. B cell depletion therapy, including rituximab, is an important strategy for ABO-incompatible transplants. However, knowledge about the effect of B cell depletion therapy on COVID-19 is lacking. Thirty kidney transplant recipients who developed COVID-19 were included in this study. To examine the impact of B cell depletion therapy, we retrospectively investigated the relationship between the background of the patients and the clinical outcome. Of the 30 patients, 13 received B cell depletion therapy. The median time between transplant and onset of COVID-19 was 6.1 years after transplantation; however, nine cases remained markedly depleted of CD19(+) cells (<4.0%). The patients were assigned to the normal ( n = 21) and depletion groups ( n = 9). Progression rates in the depletion and normal groups were 55.6% and 9.5%, respectively ( p = 0.014). Furthermore, the survival rate was significantly lower in the depletion group (100% in the normal group vs. 66.7% in the depletion group; p = 0.021). B cell depletion therapy may have long-term effects and increase the risk of COVID-19 in kidney transplant recipients.
Keyphrases
- pi k akt
- coronavirus disease
- sars cov
- end stage renal disease
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- stem cells
- oxidative stress
- mesenchymal stem cells
- respiratory syndrome coronavirus
- mass spectrometry
- high resolution
- free survival
- replacement therapy
- endoplasmic reticulum stress
- hodgkin lymphoma
- high speed