Integrated genomic and transcriptomic analysis reveals the activation of PI3K signaling pathway in HPV-independent cervical cancers.
Yi WangMisi HeTiancong HeXueyan OuyangXuxia ShenWanling ShiShengling HuangLibing XiangDongling ZouWei JiangHuijuan YangPublished in: British journal of cancer (2024)
This study reveals the prevalence, clinicopathology, and molecular features of HPV-ind CCs and emphasizes the importance of PIK3CA mutations and PI3K pathway activation in tumorigenesis, which suggests the potential significance of PI3Kα inhibitors in HPV-ind CC patients.
Keyphrases
- high grade
- end stage renal disease
- signaling pathway
- chronic kidney disease
- newly diagnosed
- ejection fraction
- risk factors
- prognostic factors
- peritoneal dialysis
- epithelial mesenchymal transition
- cervical cancer screening
- oxidative stress
- patient reported outcomes
- gene expression
- dna methylation
- genome wide
- protein kinase
- endoplasmic reticulum stress