Effect of intracanal cryotherapy on the inflammatory cytokine, proteolytic enzyme levels and postoperative pain in teeth with asymptomatic apical periodontitis: A randomised clinical trial.

levels might indicate that these biomarker levels can be used to predict the severity of postoperative pain. Intracanal cryotherapy was effective in reducing postoperative pain in the short term in teeth with asymptomatic apical periodontitis. Cryotherapy prevented an increase in IL-1β, IL-2, and IL-6 levels compared to the control group.