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Interplay of Mendelian and polygenic risk factors in Arab breast cancer patients.

Mohammed Al-JumaanHoyin ChuAbdullah AlsulaimanSabrina Y CampSeunghun HanRiaz GillaniYousef Al MarzooqFatmah AlmulhimChittibabu VatteAreej Al NemerAfnan AlmuhannaEliezer M Van AllenAmein Al-AliSaud H AlDubayan
Published in: Genome medicine (2023)
Overall, our study provides a framework to assess polygenic risk in an understudied population using lpWGS and identifies common variant risk as a factor independent of pathogenic variant carrier status for earlier age of onset of breast cancer among indigenous Arab breast cancer patients.
Keyphrases
  • risk factors
  • genome wide
  • breast cancer risk