Have We Neglected to Study Target-Site Drug Exposure in Children? A Systematic Review of the Literature.
Eline HermansJozefien MeersschautIsis Van HerteryckMathias DevreeseJohan Vande WallePeter De PaepePieter A J G de CockPublished in: Clinical pharmacokinetics (2024)
The influence of growth and development on drug tissue distribution continues to be a knowledge gap, due to the paucity of tissue PK data in children, especially in the younger age categories. Future research in this field should be encouraged as techniques to safely investigate drug tissue disposition in children are available.