A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation.

Andrew A MonteAlexis VestJulie HainesDanielle BerninzoniClaire HartLayne DyllaAngelo D'AlessandroKennon J HeardCheyret WoodJack Pattee

Published in: Journal of medical toxicology : official journal of the American College of Medical Toxicology (2023)

This multi'omic approach can be used to integrate metabolomic and genomic data allowing identification of genes that control downstream metabolites. These findings confirm prior work that have identified mitochondrial energy production as critical to APAP induced liver injury and have confirmed our prior work that demonstrate the importance of the urea cycle in therapeutic APAP liver injury.

Keyphrases

liver injury
drug induced
bioinformatics analysis
oxidative stress
ms ms
electronic health record
genome wide
copy number
big data
data analysis
gene expression
diabetic rats
machine learning
dna methylation
high glucose