A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling.

Tianlu JiangYiwen XiaJialun LvBowen LiYing LiSen WangZhe XuanLi XieShengkui QiuZhongyuan HeLinjun WangZe-Kuan Xu

Published in: Molecular cancer (2021)

Our study revealed that circMAPK1 inhibits the malignant biological behavior of gastric cancer cells through its encoded protein MAPK1-109aa. More importantly, circMAPK1 is a favorable predictor for gastric cancer patients and may provide a new therapeutic target in the treatment of gastric cancer.

Keyphrases

signaling pathway
oxidative stress
protein protein
pi k akt
binding protein
single cell
cell proliferation