Performance of and Severe Acute Respiratory Syndrome Coronavirus 2 Diagnostics Based on Symptom Onset and Close Contact Exposure: An Analysis From the Test Us at Home Prospective Cohort Study.
Carly HerbertBiqi WangHonghuang LinYi YanNathaniel HaferCaitlin PretzPamela StamegnaColton WrightThejas SuvarnaEmma HarmanSummer SchraderChris NowakVik KheterpalElizabeth OrvekSteven WongAdrian ZaiBruce A BartonBen S GerberStephenie C LemonAndreas FilippaiosLaura GibsonSharone GreeneAndres ColubriChad AchenbachRobert MurphyWilliam HeetderksYukari C ManabeLaurel O'ConnorNisha FaheyKatherine LuzuriagaJohn BroachKristian RothDavid D McManusApurv SoniPublished in: Open forum infectious diseases (2024)
The percent positivity for Ag-RDTs and RT-PCR tests was highest 2 days after symptom onset and 6 days after exposure, and performance increased with serial testing. The percent positivity of Ag-RDTs was lowest among asymptomatic individuals but did not differ by sex, variant, vaccination status, or age category.