Rim lesions are demonstrated in early relapsing-remitting multiple sclerosis using 3 T-based susceptibility-weighted imaging in a multi-institutional setting.
Koy Chong Ng Kee KwongDaisy MollisonRozanna MeijboomElizabeth N YorkAgniete KampaiteSarah-Jane MartinDavid P J HuntMichael J ThrippletonSiddharthan ChandranAdam D Waldmannull nullPublished in: Neuroradiology (2021)
We demonstrate that rim lesions are detectable in early-stage RRMS on 3 T MRI across multiple centres, although their relationship to lesion enlargement is equivocal in this small cohort. Identification of SWI rims was subjective. Agreed criteria for defining rim lesions and their further validation as a biomarker of chronic inflammation are required for translation of SWI into routine MS clinical practice.
Keyphrases
- multiple sclerosis
- clinical practice
- early stage
- white matter
- contrast enhanced
- magnetic resonance imaging
- oxidative stress
- high resolution
- magnetic resonance
- mass spectrometry
- rheumatoid arthritis
- squamous cell carcinoma
- disease activity
- diffusion weighted imaging
- sentinel lymph node
- network analysis
- lymph node
- photodynamic therapy