SARS-CoV-2 takes the bait: Exosomes as endogenous decoys.
Sonja FernbachBenjamin G HalePublished in: PLoS biology (2022)
Writing in PLOS Biology, Ching and colleagues show that ACE2-decorated exosomes are deployed as natural inhibitory decoys against SARS-CoV-2. High decoy levels correlate with improved patient outcomes, suggesting they directly help COVID-19 recovery and supporting the concept of successful future decoy-based therapies.