HPLC-assisted automated oligosaccharide synthesis: the implementation of the two-way split valve as a mode of complete automation.
Matteo PanzaKeith J StineAlexei V DemchenkoPublished in: Chemical communications (Cambridge, England) (2020)
Reported herein is the development of a user-friendly platform for simple and transformative automation based on standard HPLC equipment. We showcase how the improved platform works in application to the completely automated, a "press of the button," synthesis of various glycan sequences.
Keyphrases
- high throughput
- ms ms
- simultaneous determination
- machine learning
- deep learning
- high performance liquid chromatography
- solid phase extraction
- primary care
- aortic valve
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- mass spectrometry
- mitral valve
- tandem mass spectrometry
- single cell
- quality improvement
- aortic stenosis
- left ventricular
- high resolution
- genetic diversity
- ejection fraction