High-resolution analysis of selection sweeps identified between fine-wool Merino and coarse-wool Churra sheep breeds.
Beatriz Gutiérrez-GilCristina Esteban-BlancoPamela WienerPraveen Krishna ChitneediAroa Suarez-VegaJuan-Jose ArranzPublished in: Genetics, selection, evolution : GSE (2017)
Here, we report the mapping and genetic variation of 18 selection signatures that were identified between Australian Merino and Spanish Churra sheep breeds, which were validated by an additional contrast between Spanish Merino and Churra genotypes. Analysis of whole-genome sequencing datasets allowed us to identify divergent variants that may be viewed as candidates involved in the phenotypic differences for wool, growth and meat production/quality traits between the breeds analyzed. The four missense variants located in the NPR2, NCAPG and LCORL genes may be related to selection sweep regions previously identified and various QTL reported in sheep in relation to growth traits and carcass composition.
Keyphrases
- genome wide
- high resolution
- copy number
- genetic diversity
- dna methylation
- magnetic resonance
- air pollution
- high density
- molecular dynamics
- intellectual disability
- mass spectrometry
- molecular dynamics simulations
- magnetic resonance imaging
- gene expression
- transcription factor
- liquid chromatography
- contrast enhanced
- tandem mass spectrometry