All-trans retinoic acid modulates pigmentation, neuroretinal maturation, and corneal transparency in human multiocular organoids.

Helena Isla-MagranéMaddalen Zufiaurre-SeijoJosé García-ArumíAnna Duarri

Published in: Stem cell research & therapy (2022)

ATRA can modulate corneal epithelial integrity and transparency, photoreceptor development and maturation, and the pigmentation of RPE cells in a dose-dependent manner. These experiments revealed the high relevance of ATRA during ocular tissue development and its use as a potential new strategy to better modulate the development and maturation of ocular tissue through temporal and spatial control of ATRA signaling.

Keyphrases

induced apoptosis
induced pluripotent stem cells
cell cycle arrest
risk assessment
oxidative stress
single cell
cell death
wound healing
climate change