The Effect of Using Pazopanib With Food vs. Fasted on Pharmacokinetics, Patient Safety, and Preference (DIET Study).
Floor J E LubbermanHans GelderblomPaul HambergWalter L VervenneSasja F MulderFrank G A JansmanAngela ColbersWinette T A van der GraafDavid M BurgerSaskia LuelmoDirk Jan A R MoesCarla M L van HerpenNielka P van ErpPublished in: Clinical pharmacology and therapeutics (2019)
Pazopanib is taken fasted in a fixed oral daily dose of 800 mg. We hypothesized that ingesting pazopanib with food may improve patients' comfort and reduce gastrointestinal (GI) adverse events. Therefore, we investigated the bioequivalent dose of pazopanib when taken with food compared with 800 mg pazopanib taken fasted. In addition, we investigated the differences in GI toxicity, patient satisfaction, and patient's preference for either intake. The intake of 600 mg pazopanib with food resulted in a bioequivalent exposure and was preferred over a standard pazopanib dose without food. No differences were seen in GI toxicities under both intake regimens. Patients seem to be more positive about their feelings about side effects and satisfaction with their therapy when pazopanib was taken with food. Forty-one of the patients (68%) preferred the intake with a continental breakfast.
Keyphrases
- end stage renal disease
- patient safety
- ejection fraction
- newly diagnosed
- chronic kidney disease
- metastatic renal cell carcinoma
- prognostic factors
- physical activity
- stem cells
- oxidative stress
- patient satisfaction
- weight loss
- mass spectrometry
- mesenchymal stem cells
- climate change
- atomic force microscopy
- cell therapy
- patient reported