Double trouble: myocardial infarction with non-obstructive coronary arteries as a presentation of Hughes syndrome in monozygotic twins.
Aleksandra DjokovicL StojanovichN StanisavljevicM PopovicM ZdravkovicPublished in: Lupus (2020)
Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a recently described, clinically significant entity, with prevalence rates ranging from 1% to 14% and a mean of 6% of all patients with myocardial infarction. Antiphospholipid syndrome (APS; Hughes syndrome) is characterized by the presence of antiphospholipid antibodies associated with thrombosis (arterial and/or venous) and/or pregnancy morbidity and could be the cause of MINOCA. Data on genetic predisposition to APS are scarce. The present study describes a unique case of monozygotic twin brothers who, at a young age, developed the same clinical presentation of APS. The diagnosis of APS was later confirmed, along with a diagnosis of systemic lupus erythematosus in one brother.
Keyphrases
- systemic lupus erythematosus
- left ventricular
- heart failure
- coronary artery disease
- coronary artery
- case report
- disease activity
- aortic stenosis
- risk factors
- pulmonary embolism
- preterm birth
- genome wide
- gene expression
- dna methylation
- machine learning
- pregnant women
- copy number
- big data
- pregnancy outcomes
- atrial fibrillation