Regulation of p38 mitogen-activated kinase-mediated fetal membrane senescence by statins.

Martina T AyadBrandie DePaoli Taylor Ramkumar Menon

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)

Both simvastatin and rosuvastatin downregulated OS-induced p38MAPK activation, senescence, and SASP, while rosuvastatin showed a pronounced effect. Progesterone did not reduce OS-induced fetal membrane senescence and SASP. Simvastatin or rosuvastatin may reduce the incidences of OS-associated PTB and pPROM by preventing premature senescence and SASP.

Keyphrases

endothelial cells
high glucose
dna damage
stress induced
protein kinase
tyrosine kinase
nuclear factor