A Wrong Fate Decision in Adipose Stem Cells upon Obesity.
Yiu-Ming CheungChui Yiu Bamboo ChookHoi-Wa YeungFung-Ping LeungWing-Tak WongPublished in: Cells (2023)
Progress has been made in identifying stem cell aging as a pathological manifestation of a variety of diseases, including obesity. Adipose stem cells (ASCs) play a core role in adipocyte turnover, which maintains tissue homeostasis. Given aberrant lineage determination as a feature of stem cell aging, failure in adipogenesis is a culprit of adipose hypertrophy, resulting in adiposopathy and related complications. In this review, we elucidate how ASC fails in entering adipogenic lineage, with a specific focus on extracellular signaling pathways, epigenetic drift, metabolic reprogramming, and mechanical stretch. Nonetheless, such detrimental alternations can be reversed by guiding ASCs towards adipogenesis. Considering the pathological role of ASC aging in obesity, targeting adipogenesis as an anti-obesity treatment will be a key area of future research, and a strategy to rejuvenate tissue stem cell will be capable of alleviating metabolic syndrome.
Keyphrases
- stem cells
- insulin resistance
- high fat diet induced
- metabolic syndrome
- adipose tissue
- type diabetes
- weight loss
- skeletal muscle
- weight gain
- cell therapy
- signaling pathway
- dna methylation
- single cell
- cardiovascular risk factors
- physical activity
- deep learning
- bone marrow
- risk factors
- cancer therapy
- mesenchymal stem cells
- bone mineral density
- postmenopausal women
- solid phase extraction
- cardiovascular disease
- body composition
- smoking cessation