Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases.
Margreet R de VriesM M EwingR C M de JongM R MacArthurJ C KarperE A B PetersM NordzellS A P KarabinaD SextonI DahlbomA BergmanJ R MitchellJohan FrostegårdJ KuiperE NinioJ W JukemaK PetterssonP H A QuaxPublished in: Journal of internal medicine (2021)
Chimeric anti-PCs can prevent accelerated atherosclerosis by inhibiting vascular inflammation directly and through reduced macrophage oxLDL uptake resulting in decreased lesions. PC-mAb represents a novel strategy for cardiovascular disease prevention.