Analysis of the effect of baseline detection and early clearance of ct-DNA, on survival outcomes among patients with advanced EGFR-mutant non-small cell lung cancer.
A JoelR AbarnaR T ChackoA SinghJ T GeorgyA O JohnD B ThumatyS BalukrishnaR IsiahS PaavamaniT A KodiatteS RimaG RebekahR PaiPublished in: Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti (2024)
Baseline detection of the presence of ct-DNA of EGFR mutation in plasma was not predictive of first-line PFS, but is associated with extra thoracic disease. Patients with EGFR mutation and persistence of ct-DNA at first follow-up have worse PFS and overall survival (OS) in comparison to those clearing the same in plasma, especially among those treated with 1st/ 2nd generation EGFR TKIs.
Keyphrases
- small cell lung cancer
- epidermal growth factor receptor
- tyrosine kinase
- circulating tumor
- image quality
- dual energy
- computed tomography
- contrast enhanced
- cell free
- single molecule
- positron emission tomography
- magnetic resonance imaging
- loop mediated isothermal amplification
- label free
- spinal cord
- real time pcr
- nucleic acid
- circulating tumor cells
- newly diagnosed