Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes.

Kunihiro OtsukaKoichi YamadaYuhji TaquahashiRieko ArakakiAya UshioMasako SaitoAkiko YamadaTakaaki TsunematsuYasusei KudoJun KannoNaozumi Ishimaru

Published in: PloS one (2018)

These results suggest that T-CNT exposure promoted chronic inflammation and fibrotic lesion formation in profibrotic macrophages for prolonged periods.

Keyphrases

carbon nanotubes
oxidative stress
systemic sclerosis
idiopathic pulmonary fibrosis
drug induced